Insertion Site Similarities in the Tc 1 / Mariner Element Family
نویسنده
چکیده
We examined insertion site profiles generated from three studies of Tc1/mariner elements: Tc1 (genomic copies and experimentally induced insertions (van Luenen and Through this comparison we found that bendability, protein-induced deformability and A-philicity are the most significant for determining insertion site preference. We further examined Tn5 and Ty1 insertion sites and found that Tn5 shares similarities with the Tc1/mariner elements whereas Ty1 insertions do not. Therefore, we predict that a large amount of the Tc1/mariner elements', and possibly other DNA transposons, target site specificity relies on unusual DNA structure in the area of insertion.
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